How does conscious experience arise out of the functioning of the human brain? How is it related to the behaviour that it accompanies? How does the perceived world relate to the real world? Between them, these three questions constitute what is commonly known as the Hard Problem of consciousness. Despite vast knowledge of the relationship between brain and behaviour, and rapid advances in our knowledge of how brain activity correlates with conscious experience, the answers to all three questions remain controversial, (...) even mysterious. This important book analyses these core issues and reviews the evidence from both introspection and experiment. To many its conclusions will be surprising and even unsettling: * The entire perceived world is constructed by the brain. The relationship between the world we perceive and the underlying physical reality is not as close as we might think * Much of our behaviour is accomplished with little or no participation from conscious experience. * Our conscious experience of our behaviour lags the behaviour itself by around a fifth of a second - we become aware of what we do only after we have done it. * The lag in conscious experience applies also to the decision to act - we only become aware of our decisions after they have been formed. * The self is as much a creation of the brain as is the rest of the perceived world. Written by a leading scientist, this accessible and compelling analysis of how conscious experience relates to brain and behaviour will have major implications for our understanding of human nature. (shrink)

This important new book analyses these core issues and reviews the evidence from both introspection and experiment.

This book provides an introduction to the conceptual foundations of quantum mechanics, from classical mechanics and a discussion of the quantum phenomena that undermine our classical intuitions about how the physical world works, to the quantum measurement problem and alternatives to the standard von Neumann-Dirac formulation.

There is good reason to suppose that our best physical theories, quantum mechanics and special relativity, are false if taken together and literally. If they are in fact false, then how should they count as providing knowledge of the physical world? One might imagine that, while strictly false, our best physical theories are nevertheless in some sense probably approximately true. This paper presents a notion of local probable approximate truth in terms of descriptive nesting relations between current and subsequent theories. (...) This notion helps explain how false physical theories might nevertheless provide physical knowledge of a variety that is particularly salient to diachronic empirical inquiry. (shrink)

Jeffrey Barrett presents the most comprehensive study yet of a problem that has puzzled physicists and philosophers since the 1930s.

This paper argues for subsuming the question of open data within a larger question of information justice, with the immediate aim being to establish the need for rather than the principles of such a theory. I show that there are several problems of justice that emerge as a consequence of opening data to full public accessibility, and are generally a consequence of the failure of the open data movement to understand the constructed nature of data. I examine three such problems: (...) the embedding of social privilege in datasets as the data is constructed, the differential capabilities of data users, and the norms that data systems impose through their function as disciplinary systems. In each case I show that open data has the quite real potential to exacerbate rather than alleviate injustices. This necessitates a theory of information justice. I briefly suggest two complementary directions in which such a theory might be developed: one defining a set of moral inquiries that can be used to evaluate the justness of data practices, and another exploring the practices and structures that a social movement promoting information justice might pursue. (shrink)

_Explores how the thought of Leo Strauss amounts to a model for thinking about the connection between philosophy, Jewish thought, and history._.

Because of the measurement problem, the standard theory of quantum mechanics is at best incomplete and at worst logically inconsistent. Everett suggested that the measurement problem could be resolved by taking the linear dynamics to be a complete and accurate description of the time-evolution of every physical system. The purpose of this dissertation is to see what happens when one takes Everett's proposal seriously. This dissertation includes a discussion of the standard theory of quantum mechanics and its origins, the measurement (...) problem, Everett's relative-state formulation, the many-worlds interpretation, Albert's bare theory and its suggestive properties, and Albert and Loewer's single-mind and many-minds theories. I will show how one might construct a theory that exploits the bare theory's suggestive properties without encountering its empirical problems. (shrink)

Leo Strauss's readings of historical figures in the philosophical tradition have been justly well explored; however, his relation to contemporary thinkers has not enjoyed the same coverage. In Leo Strauss and Contemporary Thought, an international group of scholars examines the possible conversations between Strauss and figures such as Walter Benjamin, Jacques Derrida, Michel Foucault, Charles Taylor, and Hans Blumenberg. The contributors examine topics including religious liberty, the political function of comedy, law, and the relation between the Ancients and the Moderns, (...) and bring Strauss into many new and original discussions that will be of use to those interested in the thought of Strauss, the history of philosophy and political theory, and contemporary continental thought"--Back cover. (shrink)

Abstract: C. S. Peirce's psychological analysis of belief, doubt, and inquiry provides insights into the nature of scientific knowledge. These in turn can be used to construct an account of scientific knowledge where the notions of belief, truth, rational justification, and inquiry are determined by the relationships that must hold between these notions. I will describe this account of scientific knowledge and some of the problems it faces. I will also describe the close relationship between pragmatic and naturalized accounts of (...) scientific knowledge. (shrink)

The differences between the theories of hearing held by Aristotle and by Alexander of Aphrodisias are explored. Alexander appears to have a more systematic approach which avoids the dilemma faced by Aristotle in deciding whether the hearing process constitutes a time-taking kinesis or an instantaneous energeia.

Review of T. K. Johansen's book Aristotle on the sense organs. Aristotle seeks to explain the characteristics of the different sense organs by reference to the goal that they serve, that of enabling animals to perceive. A material basis is necessary for sense perception but it is an open question whether the material in question undergoes a physiological change.

I draw attention to an ambiguity of the expression ‘phenomenal consciousness’ that is an avoidable yet persistent source of conceptual confusion among consciousness scientists. The ambiguity is between what I call phenomenality and what I call conscious states, where the former denotes an abstract property and the latter denotes a phenomenon or class of its instances. Since sentences featuring these two terms have different semantic properties, it is possible to equivocate over the term ‘consciousness’. It is also possible to fail (...) to distinguish between statements that are true about conscious states in virtue of their phenomenality, and statements that are true in virtue of other properties of conscious states. I review empirically informed arguments by scientists Bernard Balleine and Anthony Dickinson, Stevan Harnad, and Jeffrey Alan Gray, arguing that each of them makes errors based on the ambiguity. I conclude with some tentative suggestions for avoiding further confusion about the ambiguity. (shrink)

A model of the neuropsychology of anxiety is proposed. The model is based in the first instance upon an analysis of the behavioural effects of the antianxiety drugs in animals. From such psychopharmacologi-cal experiments the concept of a “behavioural inhibition system” has been developed. This system responds to novel stimuli or to those associated with punishment or nonreward by inhibiting ongoing behaviour and increasing arousal and attention to the environment. It is activity in the BIS that constitutes anxiety and that (...) is reduced by antianxiety drugs. The effects of the antianxiety drugs in the brain also suggest hypotheses concerning the neural substrate of anxiety. Although the benzodiazepines and barbiturates facilitate the effects of γ-aminobutyrate, this is insufficient to explain their highly specific behavioural effects. Because of similarities between the behavioural effects of certain lesions and those of the antianxiety drugs, it is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system, the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures. Analysis of the functions of this system suggests that it acts as a comparator: it compares predicted to actual sensory events and activates the outputs of the BIS when there is a mismatch or when the predicted event is aversive. Suggestions are made as to the functions of particular pathways within this overall brain system. The resulting theory is applied to the symptoms and treatment of anxiety in man, its relations to depression, and the personality of individuals who are susceptible to anxiety or depression. (shrink)

Drawing on previous models of anxiety, intermediate memory, the positive symptoms of schizophrenia, and goal-directed behaviour, a neuropsychological hypothesis is proposed for the generation of the contents of consciousness. It is suggested that these correspond to the outputs of a comparator that, on a moment-by-moment basis, compares the current state of the organism's perceptual world with a predicted state. An outline is given of the information-processing functions of the comparator system and of the neural systems which mediate them. The hypothesis (...) appears to be able to account for a number of key features of the contents of consciousness. However, it is argued that neitherthis nor any existing comparable hypothesis is yet able to explain why the brain should generate conscious experience of any kind at all. (shrink)

Nucleosome positioning is proposed to have an essential role in facilitating the regulated transcription of eukaryotic genes. Some transcription factors can bind to DNA when it is appropriately wrapped around the histone core, others cannot bind due to the severe deformation of DNA structure. The staged assembly of nucleosomes and positioning of histone‐DNA contacts away from promoter elements can facilitate the access of transcription factors to DNA. Positioned nucleosomes can also facilitate transcription through providing the appropriate scaffolding to bring regulatory (...) factors bound at dispersed sites into juxtaposition. (shrink)

We present an exegesis of the Einstein-Podolsky-Rosen argument for the incompleteness of quantum mechanics, and defend it against the critique in Fine. (1) We contend,contra Fine, that it compares favorably with an argument reconstructed by him from a letter by Einstein to Schrödinger; and also with one given by Einstein in a letter to Popper. All three arguments turn on a dubious assumption of “separability,” which accords separate elements of reality to space-like separated systems. We discuss how this assumption figures (...) in the literature spawned by the Bell inequalities. (shrink)

The first claim in the target article was that there is as yet no transparent, causal account of the relations between consciousness and brain-and-behaviour. That claim remains firm. The second claim was that the contents of consciousness consist, psychologically, of the outputs of a comparator system; the third consisted of a description of the brain mechanisms proposed to instantiate the comparator. In order to defend these claims against criticism, it has been necessary to clarify the distinction between consciousness-as-such and the (...) contents of consciousness, to widen the description of the neural machinery instantiating the comparator system, and to clarify the relationship between the contents of consciousness in the here-and-now and episodic memory. (shrink)

Patients with end-stage renal disease experience significant mortality and morbidity, including cognitive decline. Advance care planning has been emphasized as a responsibility and priority of physicians caring for patients with chronic kidney disease in order to align with patient values before decision-making capacity is lost and to avoid suffering. This emphasis has proven ineffective, as illustrated in the case of a patient treated in our hospital. Is this ineffectiveness a consequence of failure in the courtroom or the clinic? Through our (...) own experience we affirm what has been written before: that legal precedent favors intensive treatment in virtually all cases without ‘clear and convincing evidence’ of a patient’s previously declared wishes to the contrary. Equally clear is that more than 20 years of support in the clinical literature suggesting advance care planning early in the course of disease can address challenges in the legal system for those lacking capacity. However, many physicians fail t... (shrink)

[opening paragraph]: Imagine you are a scientist from Mars observing Gary Kasparov playing a tournament with a chess computer. Would you have any reason to postulate consciousness in one player, but not the other? What is consciousness? How does the body produce it, and what is it for? Most people do not realize that there is a problem here because our conscious experience is the thing we know best. We are all familiar with the colours, smells and scenes around us, (...) the pains and itches we feel and the thoughts that are in our heads. Our world consists of conscious experiences. By `conscious experience' I mean anything that you have an awareness of, absolutely anything. I do not mean anything recondite like your capacity to reflect upon your own experiences, something which one might suppose that only we as human beings have and animals do not. I mean the absolute basics, like feeling pain. (shrink)

If the practice of maternal‐fetal medicine sometimes results in abortion, can a physician strongly opposed to abortion maintain his own integrity and still practice in this field?

As well as data indicating relationships (emphasised in the target article) (1) between dopaminergic transmission in the nucleus accumbens and positive incentive motivation, and (2) between dopaminergic transmission and extraversion, other data (not accounted for by the hypotheses developed in the target article) indicate relationships (3) between accumbens dopaminergic transmission and cognitive, especially perceptual, processes that are disrupted in schizophrenia, and (4) between dopaminergic transmission and psychoticism. The tension between relationships 1 + 2 and 3 + 4 is discussed and (...) a tentative resolution proposed. (shrink)

What makes conscious experiences necessary for in- formation processing or behaviour (no one knows)? Would it be easier first to divide consciousness into different levels (probably not)? Is consciousness tied to information processing or brain states (no one knows)? Would the target article's comparator be improved by adding a continuously adjusting feedback (probably not)?

Nucleosome positioning is proposed to have an essential role in facilitating the regulated transcription of eukaryotic genes. Some transcription factors can bind to DNA when it is appropriately wrapped around the histone core, others cannot bind due to the severe deformation of DNA structure. The staged assembly of nucleosomes and positioning of histone‐DNA contacts away from promoter elements can facilitate the access of transcription factors to DNA. Positioned nucleosomes can also facilitate transcription through providing the appropriate scaffolding to bring regulatory (...) factors bound at dispersed sites into juxtaposition. (shrink)